Reviewed: MR in pulmonary hypertension and RV failure

Pulmonary hypertension (PH) is characterized by pulmonary vascular remodelling, leading to progressive increase in pulmonary artery pressure and subsequent right ventricular failure. Aldosterone and the mineralocorticoid receptor (MR) are key ...

Cytokine adsorption with CytoSorb in patients requiring ECMO for severe COVID-19 pneumonia

It was hypothesized that increased cytokine levels may lead to negative outcomes of patients with severe COVID-19. In a single-centre, open-label, randomized, controlled trial conducted at the Freiburg University Medical ...

Endothelial cell mineralocorticoid receptors drive pulmonary hypertension and RV failure

Mineralocorticoid receptor (MR) antagonists are well established in the treatment of chronic left heart disease, however, there is an ever growing body of evidence suggesting potential benefits in other cardiovascular ...