Single Nucleus RNAseq reveals Reversible Fibroblast Trajectories in HFpEF
Background: Heart failure with preserved ejection fraction (HFpEF) is a major health issue of our time. The pathophysiology of HFpEF is diverse, linked to comorbidities, such as kidney disease or...
DFG supports new Research Unit FOR6051
Major research funding for an overlooked tissue constiuent in the heart The German Research Foundation (DFG) is supporting a new Freiburg-based Research Unit investigating the role of the interstitium as...
Aldosterone and MR in atrial fibrillation
In our recent article, we review what is currently known about the role of aldosterone and the mineralocorticoid receptor in atrial fibrillation, summarize the mechanistic basis as supported by experimental...
Regulation endothelial cell cycle arrest at the transition from cardiac hypertrophy to heart failure
Increased load leads to cardiac hypertrophy and endothelial cells play a vital role in maintaining oxygen supply to the heart through angiogenesis. However, insufficient angiogenesis contributes to the progression of...
Cell Type–Resolved Transcriptome of Aldosterone-Induced Atrial Myopathy and Arrhythmia
There is emerging evidence that mineralocorticoid receptor antagonists reduce the burden of atrial fibrillation in patients with or without heart failure. In this study, we show that aldosterone infusion drives...
Gene expression networks in endothelial cells from failing human hearts
Chronic heart failure is associated with adverse remodeling of the heart that is typically characterized by cardiomyocyte hypertrophy. This requires the formation of new capillaries to maintain oxygen supply. Insufficient...