Cardiac injury and gene expression induced by catecholamine treatment is largely reversible

Catecholamines are commonly used as therapeutic drugs in intensive care medicine to maintain sufficient organ perfusion during shock. However, excessive or sustained adrenergic activation drives detrimental cardiac remodeling and may...

Epigenome and 3D chromatin structure of cardiac endothelial cells

Endothelial cells play crucial roles in physiology and are increasingly recognized as therapeutic targets in cardio-vascular disease. Here, we analyzed the regulatory landscape of cardiac endothelial cells by assessing chromatin...

2024 Joint Meeting of ESAC & ADMIRE Network

Registration and abstract submission for the 2024 Joint Meeting of ESAC and the ADMIRE network is now open: meeting.admire-network.org...

Molecular pharmacology of mineralocorticoid receptor antagonists

Mineralocorticoid receptor (MR) antagonists have shown remarkable benefits in the treatment of cardiovascular disease. However, their underutilization in clinical practice may be attributed to concerns regarding the risk of hyperkalemia...

Cell types of the heart: identities, interactions, and implications for cardiology

The heterocellular nature of the heart has been receiving increasing attention in recent years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes such as endothelial...

Therapeutic targeting of mineralocorticoid receptors in pulmonary hypertension

Pulmonary hypertension (PH) is characterized by pulmonary vascular remodeling and associated with adverse outcomes. In patients with PH, plasma aldosterone levels are elevated, suggesting that aldosterone and its receptor, the...