MR antagonists have proven to be highly efficient in patients with heart failure and reduced ejection fraction, and they are a cornerstone of contemporary therapy. In the past decade, a series of experimental studies using models with cell type–specific MRs uncovered the more…
Mineralocorticoid receptor antagonists (MRAs) are highly effective therapies for cardiovascular and renal disease. However, the widespread clinical use of currently available MRAs in cardiorenal medicine is hampered by an increased risk of hyperkalemia. The mineralocorticoid receptor (MR) is a nuclear more…
Endothelial cells provide a variety of highly specialized functions in different organs, e.g. as barrier, as sensor, or in nutrition supply, and cardiac endothelial cells play an important role in cardiovascular biology and disease. In this study we performed RNAseq more…
