Reviewed: MR in pulmonary hypertension and RV failure

Pulmonary hypertension (PH) is characterized by pulmonary vascular remodelling, leading to progressive increase in pulmonary artery pressure and subsequent right ventricular failure. Aldosterone and the mineralocorticoid receptor (MR) are key drivers of cardiovascular disease and MR antagonists are well-established in more…

Call for Papers: Emerging fields for therapeutic targeting of the aldosterone-mineralocorticoid receptor signaling pathway

The British Journal of Pharmacology will be publishing a special ‘Themed Issue’ entitled “Emerging fields for therapeutic targeting of the aldosterone-mineralocorticoid receptor signaling pathway” with Achim Lother, Ulrich Wenzel and Frédéric Jaisser as Guest Editors. Call for papers: https://bpspubs.onlinelibrary.wiley.com/hub/journal/14765381/aldosterone-mineralocorticoid.html

No increased activity of the renin-angiotensin-aldosterone system in patients with COVID-19

The role of the renin-angiotensin-aldosterone system in the corona virus-induced disease COVID-19 is controversially discussed. SARS-CoV-2 enters host cells by binding to angiotensin-converting enzyme 2 and activity of the renin-angiotensin-aldosterone system may affect susceptibility to SARS-CoV-2 infection and outcome of more…