Therapeutic targeting of mineralocorticoid receptors in pulmonary hypertension

Pulmonary hypertension (PH) is characterized by pulmonary vascular remodeling and associated with adverse outcomes. In patients with PH, plasma aldosterone levels are elevated, suggesting that aldosterone and its receptor, the mineralocorticoid receptor (MR), play an important role in the pathophysiology more…

BJP Themed Issue: Therapeutic targeting of the aldosterone–mineralocorticoid receptor signaling pathway

During the past few years enormous research activities substantially advanced our understanding of the molecular, cellular, and pathophysiological functions of the MR. The British Journal of Pharmacology now publishs a themed issue summarizing the current knowledge of the aldosterone-MR signaling more…