Gene expression networks in endothelial cells from failing human hearts (transcriptome, human)
RNA-seq from isolated endothelial cells of human left ventricle
Bioproject: PRJNA1128383
Reference: Wirth et al. Am J Physiol Heart Circ Physiol 2024 PMID 39028282
Isoprenaline/phenylephrine- and Endothelin-1-induced gene expression in cardiomyocytes (transcriptome, mouse)
RNA-seq from isolated cardiac myocyte nuclei after treatment with Isoprenaline/phenylephrine or endothelin-1 with or without 2 week recovery period
Bioproject: PRJNA1027750
Reference: Bode et al. Intensive Care Med Exp 2024 PMID 38733526
Atlas of cardiac endothelial cell enhancer elements (transcriptome, ChIP, Hi-C, mouse)
Cardiac endothelial cell epigenome, Hi-C, and RNA-seq of various injury models
BioProject: PRJNA945592, PRJNA972993, and PRJNA989417
Reference: Deng et al. Sci Adv 2024 PMID 38446896
Impact of epigenetic inhibitors on Endothelin-1 induced gene expression in ESC derived cardiomyocytes (transcriptome, ChIP, mouse)
RNA-seq, ChIP-seq of histone modifications, ChIP-seq of HDAC6 and BRD4 in ESC derived cardiomyocytes with and without Endothelin-1 treatment and/or epigenetic inhibitors
BioProject: PRJNA788870
Reference: Ngo et al. J Am Heart Assoc 2022; PMID 35699165
Cell type-specific response to diabetes in cardiac cells (transcriptome, DNA methylome, mouse)
RNA-seq and whole-genome bisulfite sequencing from isolated cardiac myocytes, endothelial cells, fibroblasts, monocytes, and macrophages untreated and in streptozotocin-induced diabetes.
BioProject: PRJNA677840 SRA: SRP292265
Reference: Lother et al. J Mol Cell Cardiol. 2021;151:74-87. PMID: 33197445
Mineralocorticoid responsive gene expression in endothelial cells (transcriptome, human)
RNA-seq of cultured humbilical vein endothelial cells after siRNA knockdown of the mineralocorticoid receptor and stimulation with aldosterone.
BioProject: PRJNA427260 SRA: SRP165263
Reference: Lother et al. J Endocrinol . PMID:30400069
Endothelial cell multi-organ comparison (transcriptome, mouse)
RNA-seq of isolated endothelial cells from mouse heart, lung, kidney, brain and skeletal muscle.
BioProject: PRJNA354710 SRA: SRP127661
Reference: Lother et al. Arterioscler Thromb Vasc Biol . PMID:29301788
Doxorubicin-induced cardiotoxicity (transcriptome, mouse)
RNA-seq of isolated wildtype and mineralocorticoid receptor-deficient cardiac myocytes after doxorubicin treatment.
BioProject: PRJNA375919 SRA: SRP102208
Reference: Lother et al. Cardiovasc Res 2018;114:282-290. PMID:28430882