We are offering a position for a PostDoc in cardiovascular epigenetics. In the planned project, we will study the interplay of transcription factors and epigenetic regulatory mechanisms in cardiovascular disease with focus on the mineralocorticoid receptor – with the aim more…
Endothelial cells play crucial roles in physiology and are increasingly recognized as therapeutic targets in cardio-vascular disease. Here, we analyzed the regulatory landscape of cardiac endothelial cells by assessing chromatin accessibility, histone modifications, and 3D chromatin organization and confirmed the more…
Mineralocorticoid receptor (MR) antagonists have shown remarkable benefits in the treatment of cardiovascular disease. However, their underutilization in clinical practice may be attributed to concerns regarding the risk of hyperkalemia. An ideal selective MR modulator would inhibit the detrimental effects more…
