The role of the renin-angiotensin-aldosterone system in the corona virus-induced disease COVID-19 is controversially discussed. SARS-CoV-2 enters host cells by binding to angiotensin-converting enzyme 2 and activity of the renin-angiotensin-aldosterone system may affect susceptibility to SARS-CoV-2 infection and outcome of more…
Angiogenesis is an important adaptive mechanism to maintain capillary density during cardiac hypertrophic growth and ensure oxygen and nutrition supply. Aldosterone and the mineralocorticoid receptor (MR) are key drivers of adverse cardiovascular remodeling. Using a cell type-specific deletion model we more…
MR in endothelial cells and vascular smooth muscle cells are decisive mediators of cardiovascular remodeling. They contribute to blood pressure regulation and link cardiovascular risk factors and disease. Different cellular and molecular mechanisms that are involved in these effects could be identified more…
