Vascular Mineralocorticoid Receptors: Linking Risk Factors, Hypertension, and Heart Disease

MR in endothelial cells and vascular smooth muscle cells are decisive mediators of cardiovascular remodeling. They contribute to blood pressure regulation and link cardiovascular risk factors and disease. Different cellular and molecular mechanisms that are involved in these effects could be identified more…

Endothelial MR in hypertensive heart vs. kidney disease

Long-term arterial hypertension leads to heart and kidney injury. The goal of our study was to evaluate the effect of MR deletion in endothelial cells on organ damage in a model of deoxycorticosterone acetate/salt–induced hypertension. MR deletion reduced expression of more…

Recurrent pulseless electrical activity in a patient with coronary vasospasm and supravalvular aortic stenosis

Pulseless electrical activity cardiac arrest is associated with poor outcomes and the identification of potentially reversible reasons for cardiac arrest is fundamental. We describe the case of a 46-year-old male with the rare coincidental finding of supravalvular aortic stenosis and more…