Long-term arterial hypertension leads to heart and kidney injury. The goal of our study was to evaluate the effect of MR deletion in endothelial cells on organ damage in a model of deoxycorticosterone acetate/salt–induced hypertension. MR deletion reduced expression of more…
Pulseless electrical activity cardiac arrest is associated with poor outcomes and the identification of potentially reversible reasons for cardiac arrest is fundamental. We describe the case of a 46-year-old male with the rare coincidental finding of supravalvular aortic stenosis and more…
Aldosterone regulates water and electrolyte homeostasis by activation of the mineralocorticoid receptor (MR), a ligand-activated transcription factor, in the kidney. Clinical trials have shown a striking benefit of MR antagonists in chronic heart failure and post-myocardial infarction treatment. Experimental studies more…
