In our recent article, we review what is currently known about the role of aldosterone and the mineralocorticoid receptor in atrial fibrillation, summarize the mechanistic basis as supported by experimental studies, and discuss the potential of mineralocorticoid receptor antagonists in more…
Increased load leads to cardiac hypertrophy and endothelial cells play a vital role in maintaining oxygen supply to the heart through angiogenesis. However, insufficient angiogenesis contributes to the progression of heart failure. In our latest study, led by Elias Erny, more…
There is emerging evidence that mineralocorticoid receptor antagonists reduce the burden of atrial fibrillation in patients with or without heart failure. In this study, we show that aldosterone infusion drives atrial remodeling in mice and increases the risk for arrhythmia. more…
