The heterocellular heart requires cell type-specific epigenetic analysis to uncover the impact of diabetes

The heterocellular heart requires cell type-specific epigenetic analysis to uncover the impact of diabetes

The aim of this study was to investigate the impact of diabetes on gene expression and DNA methylation in cardiac cells. Cell type-specific analysis performed in this study reveals differentially ...
No increased activity of the renin-angiotensin-aldosterone system in patients with COVID-19

No increased activity of the renin-angiotensin-aldosterone system in patients with COVID-19

The role of the renin-angiotensin-aldosterone system in the corona virus-induced disease COVID-19 is controversially discussed. SARS-CoV-2 enters host cells by binding to angiotensin-converting enzyme 2 and activity of the renin-angiotensin-aldosterone ...
Bleeding defines the in-hospital outcome of patients with atrial fibrillation after TF-TAVR

Bleeding defines the in-hospital outcome of patients with atrial fibrillation after TF-TAVR

We analyzed all 57,050 cases of TF-TAVR between 2008 and 2016 in Germany, of which 44.2% had AF. Patients with AF were at higher risk for unfavorable in-hospital outcome after ...