Protein profiling gives insight into the pathophysiology of COVID-19 and reveals potential biomarkers
COVID-19 is associated with a complex disorder of pro-inflammatory and anti-viral responses, including disturbed interferon signaling. In a prospective single-center registry supported by the German Center for Infection Research, we ...
The heterocellular heart requires cell type-specific epigenetic analysis to uncover the impact of diabetes
The aim of this study was to investigate the impact of diabetes on gene expression and DNA methylation in cardiac cells. Cell type-specific analysis performed in this study reveals differentially ...
No increased activity of the renin-angiotensin-aldosterone system in patients with COVID-19
The role of the renin-angiotensin-aldosterone system in the corona virus-induced disease COVID-19 is controversially discussed. SARS-CoV-2 enters host cells by binding to angiotensin-converting enzyme 2 and activity of the renin-angiotensin-aldosterone ...