During the past few years enormous research activities substantially advanced our understanding of the molecular, cellular, and pathophysiological functions of the MR. The British Journal of Pharmacology now publishs a ...

MR antagonists have proven to be highly efficient in patients with heart failure and reduced ejection fraction, and they are a cornerstone of contemporary therapy. In the past decade, a series of ...

The German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) supports the formation of a scientific network on 'Strategies for therapeutic targeting of the Aldosterone-Mineralocorticoid Receptor signaling pathway' (Speaker: Achim Lother). The network ...

Mineralocorticoid receptor antagonists (MRAs) are highly effective therapies for cardiovascular and renal disease. However, the widespread clinical use of currently available MRAs in cardiorenal medicine is hampered by an increased ...

Pulmonary hypertension (PH) is characterized by pulmonary vascular remodelling, leading to progressive increase in pulmonary artery pressure and subsequent right ventricular failure. Aldosterone and the mineralocorticoid receptor (MR) are key ...

It was hypothesized that increased cytokine levels may lead to negative outcomes of patients with severe COVID-19. In a single-centre, open-label, randomized, controlled trial conducted at the Freiburg University Medical ...