Archive

We are offering a position for a PostDoc in cardiovascular epigenetics. In the planned project, we will study the interplay of transcription factors and epigenetic regulatory mechanisms in cardiovascular disease...

Endothelial cells play crucial roles in physiology and are increasingly recognized as therapeutic targets in cardio-vascular disease. Here, we analyzed the regulatory landscape of cardiac endothelial cells by assessing chromatin...

Registration and abstract submission for the 2024 Joint Meeting of ESAC and the ADMIRE network is now open: meeting.admire-network.org...

Mineralocorticoid receptor (MR) antagonists have shown remarkable benefits in the treatment of cardiovascular disease. However, their underutilization in clinical practice may be attributed to concerns regarding the risk of hyperkalemia...

The heterocellular nature of the heart has been receiving increasing attention in recent years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes such as endothelial...

Pulmonary hypertension (PH) is characterized by pulmonary vascular remodeling and associated with adverse outcomes. In patients with PH, plasma aldosterone levels are elevated, suggesting that aldosterone and its receptor, the...

We are proud to participate in a newly established program training the cardiovascular scientists of tomorrow: The English-language MSc Medical Sciences – Cardiovascular Research is a 1-year program, combining taught (first term)...

The ADMIRE network organizes a virtual lecture series that aims to strengthen the exchange between scientists working on aldosterone, the mineralocorticoid receptor, or related topics worldwide. The forum is open...

Epigenetic modulators have been proposed as promising new drug targets to treat adverse remodeling in heart failure. Here, we evaluated the potential of 4 epigenetic drugs, including the pan-BRD (bromodomain-containing...

During the past few years enormous research activities substantially advanced our understanding of the molecular, cellular, and pathophysiological functions of the MR. The British Journal of Pharmacology now publishs a...

MR antagonists have proven to be highly efficient in patients with heart failure and reduced ejection fraction, and they are a cornerstone of contemporary therapy. In the past decade, a series of...

The German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) supports the formation of a scientific network on ‘Strategies for therapeutic targeting of the Aldosterone-Mineralocorticoid Receptor signaling pathway’ (Speaker: Achim Lother). The network...

Mineralocorticoid receptor antagonists (MRAs) are highly effective therapies for cardiovascular and renal disease. However, the widespread clinical use of currently available MRAs in cardiorenal medicine is hampered by an increased...

Mineralocorticoid receptor (MR) antagonists are well established in the treatment of chronic left heart disease, however, there is an ever growing body of evidence suggesting potential benefits in other cardiovascular...

Both, antiviral treatment with remdesivir and hemoadsorption using a CytoSorb® adsorption device are applied in the treatment of severe COVID-19. The CytoSorb® adsorber consists of porous polymer beads that adsorb...

COVID-19 is associated with a complex disorder of pro-inflammatory and anti-viral responses, including disturbed interferon signaling. In a prospective single-center registry supported by the German Center for Infection Research, we...

The aim of this study was to investigate the impact of diabetes on gene expression and DNA methylation in cardiac cells. Cell type-specific analysis performed in this study reveals differentially...

The role of the renin-angiotensin-aldosterone system in the corona virus-induced disease COVID-19 is controversially discussed. SARS-CoV-2 enters host cells by binding to angiotensin-converting enzyme 2 and activity of the renin-angiotensin-aldosterone...

We analyzed all 57,050 cases of TF-TAVR between 2008 and 2016 in Germany, of which 44.2% had AF. Patients with AF were at higher risk for unfavorable in-hospital outcome after...

The newly established German Collaborative Research Centre (SFB1425) “Heterocellular Nature of Cardiac Lesions: Identities, Interactions, Implications” is recruiting 13 PhD students and 5 post-docs to join cutting-edge research that aims...

The German Research Foundation (DFG) has approved the application for a Collaborative Research Center on the “Heterocellular Nature of Cardiac Lesions – Identities, Interactions, Implications” (CRC 1425). Press release DFGPress...

Luisa Wirth receives a Kaltenbach fellowship of the German Heart Foundation – congratulations! Luisa is a medical student in the Cardiovascular Pharmacology Research Group working on gene expression in endothelial...

Endothelial cells take pivotal roles in the heart and the vascular system and their differentiation, subspecification and function is determined by cell type- and organ-specific gene expression (Lother & Bergemann...

Jessica Kowalski, MD student and Cardiovascular Pharmacology Research Group member, successfully completed her Otto Hess Scholarship, funded by the German Cardiac Society. For her work on the cell type-specific role...

“Aldosterone-Mineralocorticoid Receptor – Cell Biology to Translational Medicine” edited by Brian Harvey is now online. The open-access book assembles review chapters from 16 European laboratories taking part in the EU...

At this year’s annual meeting of the German Cardiac Society (DGK), MD student Jessica Kowalski gained the 2nd prize at the Hans Blömer young investigator award competition. She was awarded...

Angiogenesis is an important adaptive mechanism to maintain capillary density during cardiac hypertrophic growth and ensure oxygen and nutrition supply. Aldosterone and the mineralocorticoid receptor (MR) are key drivers of...

The 2nd Cardiovasvular Epigenetics Conference featuring well-recognized international speakers will take place in Freiburg, September 24th and 25th, 2018. Visit http://portal.uni-freiburg.de/pharmakologie for further information and registration...

Lisa Deng is awarded with a poster prize at this year’s annual meeting of the German Cardiac Society (DGK) for her presentation “Endothelial mineralocorticoid receptor deletion alters cardiac macrophage gene expression...

Anthracyclines such as doxorubicin are widely used in cancer therapy but their use is limited by cardiotoxicity. Up to date there is no established strategy for the prevention of anthracyclin-induced...

MD student Jessica Kowalski receives a prestigious Otto-Hess-Scholarship from the German Cardiac Society for her work on mineralocorticoid receptors in the cardiovascular system. With the scholarship, the society aims to...

Endothelial cells provide a variety of highly specialized functions in different organs, e.g. as barrier, as sensor, or in nutrition supply, and cardiac endothelial cells play an important role in...

The Cardiac Epigenome Browser is a resource for cell-type specific cardiac chromatin interaction and epigenome data. The project is located at the Institute of experimental and clinical Pharmacology and Toxicology...

Dr. Achim Lother received the Heart Center Freiburg University Young Investigator Award during this year’s UHZ Lecture. The Lecture was given by systems biology pioneer Professor Denis Noble, CBE FRS...