Cell Type–Resolved Transcriptome of Aldosterone-Induced Atrial Myopathy and Arrhythmia

There is emerging evidence that mineralocorticoid receptor antagonists reduce the burden of atrial fibrillation in patients with or without heart failure. In this study, we show that aldosterone infusion drives atrial remodeling in mice and increases the risk for arrhythmia. more…

Therapeutic targeting of mineralocorticoid receptors in pulmonary hypertension

Pulmonary hypertension (PH) is characterized by pulmonary vascular remodeling and associated with adverse outcomes. In patients with PH, plasma aldosterone levels are elevated, suggesting that aldosterone and its receptor, the mineralocorticoid receptor (MR), play an important role in the pathophysiology more…