Increased load leads to cardiac hypertrophy and endothelial cells play a vital role in maintaining oxygen supply to the heart through angiogenesis. However, insufficient angiogenesis contributes to the progression of heart failure. In our latest study, led by Elias Erny, more…
Chronic heart failure is associated with adverse remodeling of the heart that is typically characterized by cardiomyocyte hypertrophy. This requires the formation of new capillaries to maintain oxygen supply. Insufficient angiogenesis promotes the transition from compensated hypertrophy into heart failure. more…
Endothelial cells play crucial roles in physiology and are increasingly recognized as therapeutic targets in cardio-vascular disease. Here, we analyzed the regulatory landscape of cardiac endothelial cells by assessing chromatin accessibility, histone modifications, and 3D chromatin organization and confirmed the more…
