Cell Type–Resolved Transcriptome of Aldosterone-Induced Atrial Myopathy and Arrhythmia

There is emerging evidence that mineralocorticoid receptor antagonists reduce the burden of atrial fibrillation in patients with or without heart failure. In this study, we show that aldosterone infusion drives atrial remodeling in mice and increases the risk for arrhythmia. more…

Epigenome and 3D chromatin structure of cardiac endothelial cells

Endothelial cells play crucial roles in physiology and are increasingly recognized as therapeutic targets in cardio-vascular disease. Here, we analyzed the regulatory landscape of cardiac endothelial cells by assessing chromatin accessibility, histone modifications, and 3D chromatin organization and confirmed the more…