Protein profiling gives insight into the pathophysiology of COVID-19 and reveals potential biomarkers

COVID-19 is associated with a complex disorder of pro-inflammatory and anti-viral responses, including disturbed interferon signaling. In a prospective single-center registry supported by the German Center for Infection Research, we compared serum protein expression profiles of SARS-CoV-2 positive patients and more…

The heterocellular heart requires cell type-specific epigenetic analysis to uncover the impact of diabetes

The aim of this study was to investigate the impact of diabetes on gene expression and DNA methylation in cardiac cells. Cell type-specific analysis performed in this study reveals differentially regulated gene programs in diabetes that are associated with disease-relevant more…

No increased activity of the renin-angiotensin-aldosterone system in patients with COVID-19

The role of the renin-angiotensin-aldosterone system in the corona virus-induced disease COVID-19 is controversially discussed. SARS-CoV-2 enters host cells by binding to angiotensin-converting enzyme 2 and activity of the renin-angiotensin-aldosterone system may affect susceptibility to SARS-CoV-2 infection and outcome of more…