Pulmonary hypertension (PH) is characterized by pulmonary vascular remodeling and associated with adverse outcomes. In patients with PH, plasma aldosterone levels are elevated, suggesting that aldosterone and its receptor, the mineralocorticoid receptor (MR), play an important role in the pathophysiology more…
Mineralocorticoid receptor (MR) antagonists are well established in the treatment of chronic left heart disease, however, there is an ever growing body of evidence suggesting potential benefits in other cardiovascular disease. Here, we evaluated the effects of MR antagonists on more…
Jessica Kowalski, MD student and Cardiovascular Pharmacology Research Group member, successfully completed her Otto Hess Scholarship, funded by the German Cardiac Society. For her work on the cell type-specific role of the mineralocorticoid receptor in pulmonary hypertension and right heart more…
