Please see Data resources for an overview of available transcriptome and epigenome data.

  1. Rieder, M, Baldus, N, Stallmann, D, Jeserich, M, Goller, I, Wirth, L, Pollmeier, L, Hofmann, M, Bode, C, Busch, HJ, Schmid, B, Gauchel, N, Scharf, RE, Duerschmied, D, Lother, A, Krauel, K (2022) Early SARS-CoV-2 infection: platelet-neutrophil complexes and platelet function. Res Pract Thromb Haemost :100025. PMID:36575689
  2. Ankerhold, J, Giese, S, Kolb, P, Maul-Pavicic, A, Voll, RE, Göppert, N, Ciminski, K, Kreutz, C, Lother, A, Salzer, U, Bildl, W, Welsink, T, Morgenthaler, NG, Grawitz, AB, Emmerich, F, Steinmann, D, Huzly, D, Schwemmle, M, Hengel, H, Falcone, V (2022) Circulating multimeric immune complexes contribute to immunopathology in COVID-19. Nat Commun 13 (1):5654. PMID:36163132
  3. Ngo, V, Fleischmann, BK, Jung, M, Hein, L, Lother, A (2022) Histone Deacetylase 6 Inhibitor JS28 Prevents Pathological Gene Expression in Cardiac Myocytes. J Am Heart Assoc 11 (12):e025857. PMID:35699165
  4. Bauersachs, J, Lother, A (2022) Mineralocorticoid receptor activation and antagonism in cardiovascular disease: cellular and molecular mechanisms. Kidney Int Suppl (2011) 12 (1):19-26. PMID:35529088
  5. Akbil, B, Meyer, T, Stubbemann, P, Thibeault, C, Staudacher, O, Niemeyer, D, Jansen, J, Mühlemann, B, Doehn, J, Tabeling, C, Nusshag, C, Hirzel, C, Sanchez, DS, Nieters, A, Lother, A, Duerschmied, D, Schallner, N, Lieberum, JN, August, D, Rieg, S, Falcone, V, Hengel, H, Kölsch, U, Unterwalder, N, Hübner, RH, Jones, TC, Suttorp, N, Drosten, C, Warnatz, K, Spinetti, T, Schefold, JC, Dörner, T, Sander, LE, Corman, VM, Merle, U, Pa-COVID study Group, Kurth, F, von Bernuth, H, Meisel, C, Goffinet, C (2022) Early and Rapid Identification of COVID-19 Patients with Neutralizing Type I Interferon Auto-antibodies. J Clin Immunol 42 (6):1111-1129. PMID:35511314
  6. Lother, A, Jaisser, F, Wenzel, UO (2022) Emerging fields for therapeutic targeting of the aldosterone-mineralocorticoid receptor signaling pathway. Br J Pharmacol 179 (13):3099-3102. PMID:35174485
  7. Supady, A, Zahn, T, Kuhl, M, Maier, S, Benk, C, Kaier, K, Böttiger, BW, Bode, C, Lother, A, Staudacher, DL, Wengenmayer, T, Duerschmied, D (2022) Cytokine adsorption in patients with post-cardiac arrest syndrome after extracorporeal cardiopulmonary resuscitation (CYTER) - A single-centre, open-label, randomised, controlled trial. Resuscitation 173 :169-178. PMID:35143902
  8. Gauchel, N, Rieder, M, Krauel, K, Goller, I, Jeserich, M, Salzer, U, Venhoff, AC, Baldus, N, Pollmeier, L, Wirth, L, Kern, W, Rieg, S, Busch, HJ, Hofmann, M, Bode, C, Duerschmied, D, Lother, A, Heger, LA (2022) Complement system component dysregulation is a distinctive feature of COVID-19 disease: a prospective and comparative analysis of patients admitted to the emergency department for suspected COVID-19 disease. J Thromb Thrombolysis 53 (4):788-797. PMID:34904186
  9. Clarisse, D, Deng, L, de Bosscher, K, Lother, A (2022) Approaches towards tissue-selective pharmacology of the mineralocorticoid receptor. Br J Pharmacol 179 (13):3235-3249. PMID:34698367
  10. Lother, A, Bode, C, Hein, L (2021) Letter by Lother et al Regarding Article, "Finerenone and Cardiovascular Outcomes in Patients With Chronic Kidney Disease and Type 2 Diabetes". Circulation 144 (11):e201. PMID:34516302
  11. Mamazhakypov, A, Hein, L, Lother, A (2022) Mineralocorticoid receptors in pulmonary hypertension and right heart failure: From molecular biology to therapeutic targeting. Pharmacol Ther 231 :107987. PMID:34480966
  12. Greinacher, A, Selleng, K, Mayerle, J, Palankar, R, Wesche, J, Reiche, S, Aebischer, A, Warkentin, TE, Muenchhoff, M, Hellmuth, JC, Keppler, OT, Duerschmied, D, Lother, A, Rieg, S, Gawaz, MP, Mueller, KAL, Scheer, CS, Napp, M, Hahnenkamp, K, Lucchese, G, Vogelgesang, A, Flöel, A, Lovreglio, P, Stufano, A, Marschalek, R, Thiele, T, Immune-Response in COVID-19 Vaccination Study Group (2021) Anti-platelet factor 4 antibodies causing VITT do not cross-react with SARS-CoV-2 spike protein. Blood 138 (14):1269-1277. PMID:34280256
  13. Bauer, A, Schreinlechner, M, Sappler, N, Dolejsi, T, Tilg, H, Aulinger, BA, Weiss, G, Bellmann-Weiler, R, Adolf, C, Wolf, D, Pirklbauer, M, Graziadei, I, Gänzer, H, von Bary, C, May, AE, Wöll, E, von Scheidt, W, Rassaf, T, Duerschmied, D, Brenner, C, Kääb, S, Metzler, B, Joannidis, M, Kain, HU, Kaiser, N, Schwinger, R, Witzenbichler, B, Alber, H, Straube, F, Hartmann, N, Achenbach, S, von Bergwelt-Baildon, M, von Stülpnagel, L, Schoenherr, S, Forer, L, Embacher-Aichhorn, S, Mansmann, U, Rizas, KD, Massberg, S, ACEI-COVID investigators (2021) Discontinuation versus continuation of renin-angiotensin-system inhibitors in COVID-19 (ACEI-COVID): a prospective, parallel group, randomised, controlled, open-label trial. Lancet Respir Med 9 (8):863-872. PMID:34126053
  14. Kimura, K, Ooms, A, Graf-Riesen, K, Kuppusamy, M, Unger, A, Schuld, J, Daerr, J, Lother, A, Geisen, C, Hein, L, Takahashi, S, Li, G, Röll, W, Bloch, W, van der Ven, PFM, Linke, WA, Wu, SM, Huesgen, PF, Höhfeld, J, Fürst, DO, Fleischmann, BK, Hesse, M (2021) Overexpression of human BAG3P209L in mice causes restrictive cardiomyopathy. Nat Commun 12 (1):3575. PMID:34117258
  15. Supady, A, Weber, E, Rieder, M, Lother, A, Niklaus, T, Zahn, T, Frech, F, Müller, S, Kuhl, M, Benk, C, Maier, S, Trummer, G, Flügler, A, Krüger, K, Sekandarzad, A, Stachon, P, Zotzmann, V, Bode, C, Biever, PM, Staudacher, D, Wengenmayer, T, Graf, E, Duerschmied, D (2021) Cytokine adsorption in patients with severe COVID-19 pneumonia requiring extracorporeal membrane oxygenation (CYCOV): a single centre, open-label, randomised, controlled trial. Lancet Respir Med 9 (7):755-762. PMID:34000236
  16. Kowalski, J, Deng, L, Suennen, C, Koca, D, Meral, D, Bode, C, Hein, L, Lother, A (2021) Eplerenone Improves Pulmonary Vascular Remodeling and Hypertension by Inhibition of the Mineralocorticoid Receptor in Endothelial Cells. Hypertension 78 (2):456-465. PMID:33966455
  17. Rieder, M, Duerschmied, D, Bode, C, Lother, A (2021) Reply to Panda et al. J Infect Dis 224 (2):367-368. PMID:33955472
  18. Bemtgen, X, Rilinger, J, Jäckel, M, Zotzmann, V, Supady, A, Benk, C, Bode, C, Wengenmayer, T, Lother, A, Staudacher, DL (2021) Admission blood glucose level and outcome in patients requiring venoarterial extracorporeal membrane oxygenation. Clin Res Cardiol 110 (9):1484-1492. PMID:33944987
  19. Supady, A, Zahn, T, Rieder, M, Benk, C, Lother, A, Bode, C, Wengenmayer, T, Staudacher, D, Kellum, JA, Duerschmied, D (2022) Effect of Cytokine Adsorption on Survival and Circulatory Stabilization in Patients Receiving Extracorporeal Cardiopulmonary Resuscitation. ASAIO J 68 (1):64-72. PMID:33883508
  20. Simon-Chica, A, Fernández, MC, Wülfers, EM, Lother, A, Hilgendorf, I, Seemann, G, Ravens, U, Kohl, P, Schneider-Warme, F (2022) Novel insights into the electrophysiology of murine cardiac macrophages: relevance of voltage-gated potassium channels. Cardiovasc Res 118 (3):798-813. PMID:33823533
  21. Biever, P, Staudacher, DL, Sommer, MJ, Triebel, H, Neukamm, MA, Bode, C, Supady, A, Lother, A (2021) Hemoadsorption eliminates remdesivir from the circulation: Implications for the treatment of COVID-19. Pharmacol Res Perspect 9 (2):e00743. PMID:33710753
  22. Rieder, M, Duerschmied, D, Zahn, T, Lang, C, Benk, C, Lother, A, Biever, P, Bode, C, Wengenmayer, T, Staudacher, D, Supady, A (2021) Cytokine Adsorption in Severe Acute Respiratory Failure Requiring Veno-Venous Extracorporeal Membrane Oxygenation. ASAIO J 67 (3):332-338. PMID:33627609
  23. Hesse, M, Bednarz, R, Carls, E, Becker, C, Bondareva, O, Lother, A, Geisen, C, Dreßen, M, Krane, M, Roell, W, Hein, L, Fleischmann, BK, Gilsbach, R (2021) Proximity to injury, but neither number of nuclei nor ploidy define pathological adaptation and plasticity in cardiomyocytes. J Mol Cell Cardiol 152 :95-104. PMID:33290769
  24. Rieder, M, Wirth, L, Pollmeier, L, Jeserich, M, Goller, I, Baldus, N, Schmid, B, Busch, HJ, Hofmann, M, Thimme, R, Rieg, S, Kern, W, Bode, C, Duerschmied, D, Lother, A (2021) Serum Protein Profiling Reveals a Specific Upregulation of the Immunomodulatory Protein Progranulin in Coronavirus Disease 2019. J Infect Dis 223 (5):775-784. PMID:33249471
  25. Rieder, M, Bode, C, Duerschmied, D, Lother, A (2021) Response to "How Important Is the Assessment of Soluble ACE-2 in COVID-19?". Am J Hypertens 34 (3):298. PMID:33201224
  26. Lother, A, Bondareva, O, Saadatmand, AR, Pollmeier, L, Härdtner, C, Hilgendorf, I, Weichenhan, D, Eckstein, V, Plass, C, Bode, C, Backs, J, Hein, L, Gilsbach, R (2021) Diabetes changes gene expression but not DNA methylation in cardiac cells. J Mol Cell Cardiol 151 :74-87. PMID:33197445
  27. Rieder, M, Wirth, L, Pollmeier, L, Jeserich, M, Goller, I, Baldus, N, Schmid, B, Busch, HJ, Hofmann, M, Kern, W, Bode, C, Duerschmied, D, Lother, A (2021) Serum ACE2, Angiotensin II, and Aldosterone Levels Are Unchanged in Patients With COVID-19. Am J Hypertens 34 (3):278-281. PMID:33043967
  28. Rieder, M, Zahn, T, Benk, C, Lother, A, Bode, C, Staudacher, D, Duerschmied, D, Supady, A (2021) Cytokine adsorption in a patient with severe coronavirus disease 2019 related acute respiratory distress syndrome requiring extracorporeal membrane oxygenation therapy: A case report. Artif Organs 45 (2):191-194. PMID:32929761
  29. Lother, A, Kaier, K, Ahrens, I, Bothe, W, Wolf, D, Zehender, M, Bode, C, von Zur Mühlen, C, Stachon, P (2020) Bleeding Complications Drive In-Hospital Mortality of Patients with Atrial Fibrillation after Transcatheter Aortic Valve Replacement. Thromb Haemost 120 (11):1580-1586. PMID:32828074
  30. Supady, A, Duerschmied, D, Bode, C, Rieder, M, Lother, A (2020) Extracorporeal cytokine adsorption as an alternative to pharmacological inhibition of IL-6 in COVID-19. Crit Care 24 (1):514. PMID:32819415
  31. Lother, A (2020) Mineralocorticoid Receptors: Master Regulators of Extracellular Matrix Remodeling. Circ Res 127 (3):354-356. PMID:32673533
  32. Rieder, M, Goller, I, Jeserich, M, Baldus, N, Pollmeier, L, Wirth, L, Supady, A, Bode, C, Busch, HJ, Schmid, B, Duerschmied, D, Gauchel, N, Lother, A (2020) Rate of venous thromboembolism in a prospective all-comers cohort with COVID-19. J Thromb Thrombolysis 50 (3):558-566. PMID:32617807
  33. Lang, CN, Sommer, MJ, Neukamm, MA, Staudacher, DL, Supady, A, Bode, C, Duerschmied, D, Lother, A (2020) Use of the CytoSorb adsorption device in MDMA intoxication: a first-in-man application and in vitro study. Intensive Care Med Exp 8 (1):21. PMID:32542550
  34. Decker, A, Welzel, M, Laubner, K, Grundmann, S, Kochs, G, Panning, M, Thimme, R, Bode, C, Wagner, D, Lother, A (2020) Prolonged SARS-CoV-2 shedding and mild course of COVID-19 in a patient after recent heart transplantation. Am J Transplant 20 (11):3239-3245. PMID:32519406
  35. Deng, L, Pollmeier, L, Zhou, Q, Bergemann, S, Bode, C, Hein, L, Lother, A (2020) Gene expression in immortalized versus primary isolated cardiac endothelial cells. Sci Rep 10 (1):2241. PMID:32042042
  36. Lother, A, Benk, C, Staudacher, DL, Supady, A, Bode, C, Wengenmayer, T, Duerschmied, D (2019) Cytokine Adsorption in Critically Ill Patients Requiring ECMO Support. Front Cardiovasc Med 6 :71. PMID:31275944
  37. Lother, A, Bode, C, Staudacher, DL (2019) Tracheostomy in Patients on Extracorporeal Membrane Oxygenation: Is it Really Safe?. J Intensive Care Med :885066619851067. PMID:31122107
  38. Lother, A, Deng, L, Huck, M, Fürst, D, Kowalski, J, Esser, JS, Moser, M, Bode, C, Hein, L (2019) Endothelial cell mineralocorticoid receptors oppose VEGF-induced gene expression and angiogenesis. J Endocrinol 240 (1):15-26. PMID:30400069
  39. Rommel, C, Rösner, S, Lother, A, Barg, M, Schwaderer, M, Gilsbach, R, Bömicke, T, Schnick, T, Mayer, S, Doll, S, Hesse, M, Kretz, O, Stiller, B, Neumann, FJ, Mann, M, Krane, M, Fleischmann, BK, Ravens, U, Hein, L (2018) The Transcription Factor ETV1 Induces Atrial Remodeling and Arrhythmia. Circ Res 123 (5):550-563. PMID:29930145
  40. Lother, A, Bergemann, S, Deng, L, Moser, M, Bode, C, Hein, L (2018) Cardiac Endothelial Cell Transcriptome. Arterioscler Thromb Vasc Biol 38 (3):566-574. PMID:29301788
  41. Lother, A, Bergemann, S, Kowalski, J, Huck, M, Gilsbach, R, Bode, C, Hein, L (2018) Inhibition of the cardiac myocyte mineralocorticoid receptor ameliorates doxorubicin-induced cardiotoxicity. Cardiovasc Res 114 (2):282-290. PMID:28430882
  42. Esser, JS, Charlet, A, Schmidt, M, Heck, S, Allen, A, Lother, A, Epting, D, Patterson, C, Bode, C, Moser, M (2017) The neuronal transcription factor NPAS4 is a strong inducer of sprouting angiogenesis and tip cell formation. Cardiovasc Res 113 (2):222-223. PMID:28082451
  43. Beetz, N, Rommel, C, Schnick, T, Neumann, E, Lother, A, Monroy-Ordonez, EB, Zeeb, M, Preissl, S, Gilsbach, R, Melchior-Becker, A, Rylski, B, Stoll, M, Schaefer, L, Beyersdorf, F, Stiller, B, Hein, L (2016) Ablation of biglycan attenuates cardiac hypertrophy and fibrosis after left ventricular pressure overload. J Mol Cell Cardiol 101 :145-155. PMID:27789290
  44. Lother, A, Hein, L (2016) Pharmacology of heart failure: From basic science to novel therapies. Pharmacol Ther 166 :136-49. PMID:27456554
  45. Lother, A, Wengenmayer, T, Benk, C, Bode, C, Staudacher, DL (2016) Fatal air embolism as complication of percutaneous dilatational tracheostomy on venovenous extracorporeal membrane oxygenation, two case reports. J Cardiothorac Surg 11 (1):102. PMID:27401983
  46. Lother, A, Hein, L (2016) Vascular Mineralocorticoid Receptors: Linking Risk Factors, Hypertension, and Heart Disease. Hypertension 68 (1):6-10. PMID:27217405
  47. Lother, A, Beyersdorf, F, Osterhues, HH, Bode, C, Wengenmayer, T (2016) Recurrent pulseless electrical activity in a patient with coronary vasospasm and supravalvular aortic stenosis: a case report. BMC Cardiovasc Disord 16 :100. PMID:27216437
  48. Lother, A, Fürst, D, Bergemann, S, Gilsbach, R, Grahammer, F, Huber, TB, Hilgendorf, I, Bode, C, Moser, M, Hein, L (2016) Deoxycorticosterone Acetate/Salt-Induced Cardiac But Not Renal Injury Is Mediated By Endothelial Mineralocorticoid Receptors Independently From Blood Pressure. Hypertension 67 (1):130-8. PMID:26553231
  49. Koentges, C, Pfeil, K, Meyer-Steenbuck, M, Lother, A, Hoffmann, MM, Odening, KE, Hein, L, Bode, C, Bugger, H (2016) Preserved recovery of cardiac function following ischemia-reperfusion in mice lacking SIRT3. Can J Physiol Pharmacol 94 (1):72-80. PMID:26524632
  50. Mayer, SC, Gilsbach, R, Preissl, S, Monroy Ordonez, EB, Schnick, T, Beetz, N, Lother, A, Rommel, C, Ihle, H, Bugger, H, Rühle, F, Schrepper, A, Schwarzer, M, Heilmann, C, Bönisch, U, Gupta, SK, Wilpert, J, Kretz, O, von Elverfeldt, D, Orth, J, Aktories, K, Beyersdorf, F, Bode, C, Stiller, B, Krüger, M, Thum, T, Doenst, T, Stoll, M, Hein, L (2015) Adrenergic Repression of the Epigenetic Reader MeCP2 Facilitates Cardiac Adaptation in Chronic Heart Failure. Circ Res 117 (7):622-33. PMID:26195221
  51. Lother, A, Moser, M, Bode, C, Feldman, RD, Hein, L (2015) Mineralocorticoids in the heart and vasculature: new insights for old hormones. Annu Rev Pharmacol Toxicol 55 :289-312. PMID:25251996
  52. Volkmann, I, Kumarswamy, R, Pfaff, N, Fiedler, J, Dangwal, S, Holzmann, A, Batkai, S, Geffers, R, Lother, A, Hein, L, Thum, T (2013) MicroRNA-mediated epigenetic silencing of sirtuin1 contributes to impaired angiogenic responses. Circ Res 113 (8):997-1003. PMID:23960241
  53. Schneider, J, Lother, A, Hein, L, Gilsbach, R (2011) Chronic cardiac pressure overload induces adrenal medulla hypertrophy and increased catecholamine synthesis. Basic Res Cardiol 106 (4):591-602. PMID:21547520
  54. Lother, A, Berger, S, Gilsbach, R, Rösner, S, Ecke, A, Barreto, F, Bauersachs, J, Schütz, G, Hein, L (2011) Ablation of mineralocorticoid receptors in myocytes but not in fibroblasts preserves cardiac function. Hypertension 57 (4):746-54. PMID:21321305
  55. Gilsbach, R, Schneider, J, Lother, A, Schickinger, S, Leemhuis, J, Hein, L (2010) Sympathetic alpha(2)-adrenoceptors prevent cardiac hypertrophy and fibrosis in mice at baseline but not after chronic pressure overload. Cardiovasc Res 86 (3):432-42. PMID:20083574
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