The heterocellular heart requires cell type-specific epigenetic analysis to uncover the impact of diabetes

The aim of this study was to investigate the impact of diabetes on gene expression and DNA methylation in cardiac cells. Cell type-specific analysis performed in this study reveals differentially regulated gene programs in diabetes that are associated with disease-relevant more…

Mineralocorticoid Receptors: Master Regulators of Extracellular Matrix Remodeling

Mineralocorticoid receptors control extracellular matrix composition in the left ventricle and also extracardiac tissues. In the present issue of Circulation Research, the group of Natalia Lopez further extend this view, demonstrating that the aldosterone/MR signaling pathway drives mitral valve remodeling more…