Endothelial cell mineralocorticoid receptors drive pulmonary hypertension and RV failure

Mineralocorticoid receptor (MR) antagonists are well established in the treatment of chronic left heart disease, however, there is an ever growing body of evidence suggesting potential benefits in other cardiovascular disease. Here, we evaluated the effects of MR antagonists on more…

Protein profiling gives insight into the pathophysiology of COVID-19 and reveals potential biomarkers

COVID-19 is associated with a complex disorder of pro-inflammatory and anti-viral responses, including disturbed interferon signaling. In a prospective single-center registry supported by the German Center for Infection Research, we compared serum protein expression profiles of SARS-CoV-2 positive patients and more…