Protein profiling gives insight into the pathophysiology of COVID-19 and reveals potential biomarkers

COVID-19 is associated with a complex disorder of pro-inflammatory and anti-viral responses, including disturbed interferon signaling. In a prospective single-center registry supported by the German Center for Infection Research, we compared serum protein expression profiles of SARS-CoV-2 positive patients and more…

No increased activity of the renin-angiotensin-aldosterone system in patients with COVID-19

The role of the renin-angiotensin-aldosterone system in the corona virus-induced disease COVID-19 is controversially discussed. SARS-CoV-2 enters host cells by binding to angiotensin-converting enzyme 2 and activity of the renin-angiotensin-aldosterone system may affect susceptibility to SARS-CoV-2 infection and outcome of more…