Impact of epigenetic inhibitors on Endothelin-1 induced gene expression in ESC derived cardiomyocytes (transcriptome, ChIP, mouse)
RNA-seq, ChIP-seq of histone modifications, ChIP-seq of HDAC6 and BRD4 in ESC derived cardiomyocytes with and without Endothelin-1 treatment and/or epigenetic inhibitors
BioProject: PRJNA788870
Reference: Ngo et al. J Am Heart Assoc 2022; PMID 35699165
Cell type-specific response to diabetes in cardiac cells (transcriptome, DNA methylome, mouse)
RNA-seq and whole-genome bisulfite sequencing from isolated cardiac myocytes, endothelial cells, fibroblasts, monocytes, and macrophages untreated and in streptozotocin-induced diabetes.
BioProject: PRJNA677840 SRA: SRP292265
Reference: Lother et al. J Mol Cell Cardiol. 2021;151:74-87. PMID: 33197445
Mineralocorticoid responsive gene expression in endothelial cells (transcriptome, human)
RNA-seq of cultured humbilical vein endothelial cells after siRNA knockdown of the mineralocorticoid receptor and stimulation with aldosterone.
BioProject: PRJNA427260 SRA: SRP165263
Reference: Lother et al. J Endocrinol . PMID:30400069
Endothelial cell multi-organ comparison (transcriptome, mouse)
RNA-seq of isolated endothelial cells from mouse heart, lung, kidney, brain and skeletal muscle.
BioProject: PRJNA354710 SRA: SRP127661
Reference: Lother et al. Arterioscler Thromb Vasc Biol . PMID:29301788
Doxorubicin-induced cardiotoxicity (transcriptome, mouse)
RNA-seq of isolated wildtype and mineralocorticoid receptor-deficient cardiac myocytes after doxorubicin treatment.
BioProject: PRJNA375919 SRA: SRP102208
Reference: Lother et al. Cardiovasc Res 2018;114:282-290. PMID:28430882
Cardiac Epigenome Browser
The Cardiac Epigenome Browser is a resource for cell-type specific cardiac chromatin interaction and epigenome data. The project is located at the Institute of experimental and clinical Pharmacology and Toxicology, University of Freiburg, and online accessible.
Cardiac Epigenome Browser