The heterocellular heart requires cell type-specific epigenetic analysis to uncover the impact of diabetes

The aim of this study was to investigate the impact of diabetes on gene expression and DNA methylation in cardiac cells. Cell type-specific analysis performed in this study reveals differentially regulated gene programs in diabetes that are associated with disease-relevant more…

CRC 1425 “Heterocellular Nature of Cardiac Lesions” funded by the DFG

The German Research Foundation (DFG) has approved the application for a Collaborative Research Center on the “Heterocellular Nature of Cardiac Lesions – Identities, Interactions, Implications” (CRC 1425). Press release DFGPress release Heart Center Freiburg UniversityPress release University of Freiburg

Inhibition of the cardiac myocyte mineralocorticoid receptor ameliorates doxorubicin-induced cardiotoxicity

Anthracyclines such as doxorubicin are widely used in cancer therapy but their use is limited by cardiotoxicity. Up to date there is no established strategy for the prevention of anthracyclin-induced heart failure. In this study, we evaluated the role of more…