Impact of endothelial cell mineralocorticoid receptors on angiogenesis

Angiogenesis is an important adaptive mechanism to maintain capillary density during cardiac hypertrophic growth and ensure oxygen and nutrition supply. Aldosterone and the mineralocorticoid receptor (MR) are key drivers of adverse cardiovascular remodeling. Using a cell type-specific deletion model we more…

Vascular Mineralocorticoid Receptors: Linking Risk Factors, Hypertension, and Heart Disease

MR in endothelial cells and vascular smooth muscle cells are decisive mediators of cardiovascular remodeling. They contribute to blood pressure regulation and link cardiovascular risk factors and disease. Different cellular and molecular mechanisms that are involved in these effects could be identified more…

Endothelial MR in hypertensive heart vs. kidney disease

Long-term arterial hypertension leads to heart and kidney injury. The goal of our study was to evaluate the effect of MR deletion in endothelial cells on organ damage in a model of deoxycorticosterone acetate/salt–induced hypertension. MR deletion reduced expression of more…