No increased activity of the renin-angiotensin-aldosterone system in patients with COVID-19

The role of the renin-angiotensin-aldosterone system in the corona virus-induced disease COVID-19 is controversially discussed. SARS-CoV-2 enters host cells by binding to angiotensin-converting enzyme 2 and activity of the renin-angiotensin-aldosterone system may affect susceptibility to SARS-CoV-2 infection and outcome of more…

Mineralocorticoid Receptors: Master Regulators of Extracellular Matrix Remodeling

Mineralocorticoid receptors control extracellular matrix composition in the left ventricle and also extracardiac tissues. In the present issue of Circulation Research, the group of Natalia Lopez further extend this view, demonstrating that the aldosterone/MR signaling pathway drives mitral valve remodeling more…

CRC 1425 “Heterocellular Nature of Cardiac Lesions” funded by the DFG

The German Research Foundation (DFG) has approved the application for a Collaborative Research Center on the “Heterocellular Nature of Cardiac Lesions – Identities, Interactions, Implications” (CRC 1425). Press release DFGPress release Heart Center Freiburg UniversityPress release University of Freiburg