Epigenetic modulators have been proposed as promising new drug targets to treat adverse remodeling in heart failure. Here, we evaluated the potential of 4 epigenetic drugs, including the pan-BRD (bromodomain-containing protein) inhibitor bromosporine, the BET (bromodomain and extraterminal) inhibitor JQ1, more…
The aim of this study was to investigate the impact of diabetes on gene expression and DNA methylation in cardiac cells. Cell type-specific analysis performed in this study reveals differentially regulated gene programs in diabetes that are associated with disease-relevant more…
The German Research Foundation (DFG) has approved the application for a Collaborative Research Center on the “Heterocellular Nature of Cardiac Lesions – Identities, Interactions, Implications” (CRC 1425). Press release DFGPress release Heart Center Freiburg UniversityPress release University of Freiburg
