MR in endothelial cells and vascular smooth muscle cells are decisive mediators of cardiovascular remodeling. They contribute to blood pressure regulation and link cardiovascular risk factors and disease. Different cellular and molecular mechanisms that are involved in these effects could be identified more…
Long-term arterial hypertension leads to heart and kidney injury. The goal of our study was to evaluate the effect of MR deletion in endothelial cells on organ damage in a model of deoxycorticosterone acetate/salt–induced hypertension. MR deletion reduced expression of more…
Aldosterone regulates water and electrolyte homeostasis by activation of the mineralocorticoid receptor (MR), a ligand-activated transcription factor, in the kidney. Clinical trials have shown a striking benefit of MR antagonists in chronic heart failure and post-myocardial infarction treatment. Experimental studies more…
