Anthracyclines such as doxorubicin are widely used in cancer therapy but their use is limited by cardiotoxicity. Up to date there is no established strategy for the prevention of anthracyclin-induced heart failure. In this study, we evaluated the role of more…
Chronic heart failure is one of the leading causes for hospitalization in the United States and Europe, and is accompanied by high mortality. Current pharmacological therapy of chronic heart failure with reduced ejection fraction is largely based on compounds that more…
MR in endothelial cells and vascular smooth muscle cells are decisive mediators of cardiovascular remodeling. They contribute to blood pressure regulation and link cardiovascular risk factors and disease. Different cellular and molecular mechanisms that are involved in these effects could be identified more…
