Impact of endothelial cell mineralocorticoid receptors on angiogenesis

Angiogenesis is an important adaptive mechanism to maintain capillary density during cardiac hypertrophic growth and ensure oxygen and nutrition supply. Aldosterone and the mineralocorticoid receptor (MR) are key drivers of adverse cardiovascular remodeling. Using a cell type-specific deletion model we more…

Inhibition of the cardiac myocyte mineralocorticoid receptor ameliorates doxorubicin-induced cardiotoxicity

Anthracyclines such as doxorubicin are widely used in cancer therapy but their use is limited by cardiotoxicity. Up to date there is no established strategy for the prevention of anthracyclin-induced heart failure. In this study, we evaluated the role of more…