Mineralocorticoid Receptors: Master Regulators of Extracellular Matrix Remodeling

Mineralocorticoid receptors control extracellular matrix composition in the left ventricle and also extracardiac tissues. In the present issue of Circulation Research, the group of Natalia Lopez further extend this view, demonstrating that the aldosterone/MR signaling pathway drives mitral valve remodeling and suggest MR antagonists as a new therapeutic option to prevent mitral valve prolapse. Intriguingly, they show that MR the process depends on MR in endothelial cells, again highlighting the centrality of endothelial cell MR in cardiovascular disease.

Lother. Circulation Research. 2020;127:354–356 comment on
Ibarrola et al. Circulation Research. 2020;127:e80–e93