Successful Otto Hess scholarship
Jessica Kowalski, MD student and Cardiovascular Pharmacology Research Group member, successfully completed her Otto Hess Scholarship, funded by the German Cardiac Society. For her work on the cell type-specific role ...
Aldosterone-Mineralocorticoid Receptor – Cell Biology to Translational Medicine
“Aldosterone-Mineralocorticoid Receptor – Cell Biology to Translational Medicine” edited by Brian Harvey is now online. The open-access book assembles review chapters from 16 European laboratories taking part in the EU ...
Safety of tracheostomy on ECMO
Tracheostomy is recommended in case of prolonged mechanical ventilation and most patients undergoing venovenous extracorporeal membrane oxygenation (ECMO) will also have an indication for tracheostomy. However, there are several reports ...
Cytokine adsorption in patients on ECMO
In this prospective single-center registry we evaluated the use of cytokine adsorption in critically ill patients requiring extracorporeal membrane oxygenation (ECMO) support. Sepsis but also in non-infectious conditions such as ...
Successful meeting of the German Cardiac Society
At this year’s annual meeting of the German Cardiac Society (DGK), MD student Jessica Kowalski gained the 2nd prize at the Hans Blömer young investigator award competition. She was awarded ...
Impact of endothelial cell mineralocorticoid receptors on angiogenesis
Angiogenesis is an important adaptive mechanism to maintain capillary density during cardiac hypertrophic growth and ensure oxygen and nutrition supply. Aldosterone and the mineralocorticoid receptor (MR) are key drivers of ...
ESAC Meeting 2018
The ESAC Symposium 2018 on Aldosterone and the Mineralocorticoid Receptor will take place at the Friedrich-Alexander University Erlangen-Nürnberg on 7th and 8th December 2018. It will be supported by the European ...
Cardiovascular Epigenetics Conference 2018
The 2nd Cardiovasvular Epigenetics Conference featuring well-recognized international speakers will take place in Freiburg, September 24th and 25th, 2018. Visit http://portal.uni-freiburg.de/pharmakologie for further information and registration. ...
Poster prize of the German Cardiac Society
Lisa Deng is awarded with a poster prize at this year’s annual meeting of the German Cardiac Society (DGK) for her presentation “Endothelial mineralocorticoid receptor deletion alters cardiac macrophage gene expression ...
Inhibition of the cardiac myocyte mineralocorticoid receptor ameliorates doxorubicin-induced cardiotoxicity
Anthracyclines such as doxorubicin are widely used in cancer therapy but their use is limited by cardiotoxicity. Up to date there is no established strategy for the prevention of anthracyclin-induced ...
Awarded with an Otto-Hess-Scholarship
MD student Jessica Kowalski receives a prestigious Otto-Hess-Scholarship from the German Cardiac Society for her work on mineralocorticoid receptors in the cardiovascular system. With the scholarship, the society aims to ...
The cardiac endothelial cell transcriptome unravelled
Endothelial cells provide a variety of highly specialized functions in different organs, e.g. as barrier, as sensor, or in nutrition supply, and cardiac endothelial cells play an important role in ...
Browse the Cardiac Epigenome
The Cardiac Epigenome Browser is a resource for cell-type specific cardiac chromatin interaction and epigenome data. The project is located at the Institute of experimental and clinical Pharmacology and Toxicology, ...
UHZ Lecture 2017
Dr. Achim Lother received the Heart Center Freiburg University Young Investigator Award during this year’s UHZ Lecture. The Lecture was given by systems biology pioneer Professor Denis Noble, CBE FRS ...
Pharmacology of heart failure: From basic science to novel therapies
Chronic heart failure is one of the leading causes for hospitalization in the United States and Europe, and is accompanied by high mortality. Current pharmacological therapy of chronic heart failure ...
Abstract rated as Best of AHA Specialty Conferences 2016
The abstract by Lother et al., Cardiac Ly6Chigh Monocyte Accumulation and Remodeling Depend on the Mineralocorticoid Receptor in Endothelial Cells, which was presented at the American Heart Association Hypertension Council Meeting in 2016 has been ...
Vascular Mineralocorticoid Receptors: Linking Risk Factors, Hypertension, and Heart Disease
MR in endothelial cells and vascular smooth muscle cells are decisive mediators of cardiovascular remodeling. They contribute to blood pressure regulation and link cardiovascular risk factors and disease. Different cellular and molecular ...
Endothelial MR in hypertensive heart vs. kidney disease
Long-term arterial hypertension leads to heart and kidney injury. The goal of our study was to evaluate the effect of MR deletion in endothelial cells on organ damage in a ...
Recurrent pulseless electrical activity in a patient with coronary vasospasm and supravalvular aortic stenosis
Pulseless electrical activity cardiac arrest is associated with poor outcomes and the identification of potentially reversible reasons for cardiac arrest is fundamental. We describe the case of a 46-year-old male ...
Reviewed: Pharmacology of the Mineralocorticoid Receptor
Aldosterone regulates water and electrolyte homeostasis by activation of the mineralocorticoid receptor (MR), a ligand-activated transcription factor, in the kidney. Clinical trials have shown a striking benefit of MR antagonists ...