Archive

The heterocellular heart requires cell type-specific epigenetic analysis to uncover the impact of diabetes

The heterocellular heart requires cell type-specific epigenetic analysis to uncover the impact of diabetes

The aim of this study was to investigate the impact of diabetes on gene expression and DNA methylation in cardiac cells. Cell type-specific analysis performed in this study reveals differentially ...
No increased activity of the renin-angiotensin-aldosterone system in patients with COVID-19

No increased activity of the renin-angiotensin-aldosterone system in patients with COVID-19

The role of the renin-angiotensin-aldosterone system in the corona virus-induced disease COVID-19 is controversially discussed. SARS-CoV-2 enters host cells by binding to angiotensin-converting enzyme 2 and activity of the renin-angiotensin-aldosterone ...
Bleeding defines the in-hospital outcome of patients with atrial fibrillation after TF-TAVR

Bleeding defines the in-hospital outcome of patients with atrial fibrillation after TF-TAVR

We analyzed all 57,050 cases of TF-TAVR between 2008 and 2016 in Germany, of which 44.2% had AF. Patients with AF were at higher risk for unfavorable in-hospital outcome after ...

Mineralocorticoid Receptors: Master Regulators of Extracellular Matrix Remodeling

Mineralocorticoid receptors control extracellular matrix composition in the left ventricle and also extracardiac tissues. In the present issue of Circulation Research, the group of Natalia Lopez further extend this view, ...

Increased levels of D-dimers are associated with a severe course of COVID-19

We evaluated the level of D-dimers and rate of venous thromboembolic events (VTE) in a cohort of 190 patients with suspected COVID-19. After completion of a 30-days follow-up, VTE was ...

Use of the CytoSorb adsorption device in MDMA intoxication

We reported first-in-man experience and in vitro data showing the capacity of a CytoSorb adsorber device for MDMA removal.  We applied a CytoSorb adsorber device in a 21-year-old male presenting ...

COVID‐19 in heart transplant recipients: impact of immunosuppressive medication

In the coronavirus disease 2019 (COVID‐19) pandemic, organ transplant recipients are considered to be at particular high risk for infection and unfavorable outcome. We report here a case of COVID-19 ...
CRC1425: PhD and PostDoc positions available

CRC1425: PhD and PostDoc positions available

The newly established German Collaborative Research Centre (SFB1425) “Heterocellular Nature of Cardiac Lesions: Identities, Interactions, Implications” is recruiting 13 PhD students and 5 post-docs to join cutting-edge research that aims ...
CRC 1425 “Heterocellular Nature of Cardiac Lesions” funded by the DFG

CRC 1425 “Heterocellular Nature of Cardiac Lesions” funded by the DFG

The German Research Foundation (DFG) has approved the application for a Collaborative Research Center on the “Heterocellular Nature of Cardiac Lesions – Identities, Interactions, Implications” (CRC 1425). Press release DFGPress ...
Kaltenbach fellowship

Kaltenbach fellowship

Luisa Wirth receives a Kaltenbach fellowship of the German Heart Foundation – congratulations! Luisa is a medical student in the Cardiovascular Pharmacology Research Group working on gene expression in endothelial ...

PhD position available

We are offering a position for a PhD student (m/f/d) in Mineralocorticoid receptor signaling and cardiovascular epigenetics. Mineralocorticoid receptor (MR) antagonists are well-established in heart failure therapy, however, adverse effects in ...
Disturbed gene expression in immortalized endothelial cells

Disturbed gene expression in immortalized endothelial cells

Endothelial cells take pivotal roles in the heart and the vascular system and their differentiation, subspecification and function is determined by cell type- and organ-specific gene expression (Lother & Bergemann ...
Successful Otto Hess scholarship

Successful Otto Hess scholarship

Jessica Kowalski, MD student and Cardiovascular Pharmacology Research Group member, successfully completed her Otto Hess Scholarship, funded by the German Cardiac Society. For her work on the cell type-specific role ...
Aldosterone-Mineralocorticoid Receptor – Cell Biology to Translational Medicine

Aldosterone-Mineralocorticoid Receptor – Cell Biology to Translational Medicine

“Aldosterone-Mineralocorticoid Receptor – Cell Biology to Translational Medicine” edited by Brian Harvey is now online. The open-access book assembles review chapters from 16 European laboratories taking part in the EU ...

Safety of tracheostomy on ECMO

Tracheostomy is recommended in case of prolonged mechanical ventilation and most patients undergoing venovenous extracorporeal membrane oxygenation (ECMO) will also have an indication for tracheostomy. However, there are several reports ...

Cytokine adsorption in patients on ECMO

In this prospective single-center registry we evaluated the use of cytokine adsorption in critically ill patients requiring extracorporeal membrane oxygenation (ECMO) support. Sepsis but also in non-infectious conditions such as ...
Successful meeting of the German Cardiac Society

Successful meeting of the German Cardiac Society

At this year’s annual meeting of the German Cardiac Society (DGK), MD student Jessica Kowalski gained the 2nd prize at the Hans Blömer young investigator award competition. She was awarded ...
Impact of endothelial cell mineralocorticoid receptors on angiogenesis

Impact of endothelial cell mineralocorticoid receptors on angiogenesis

Angiogenesis is an important adaptive mechanism to maintain capillary density during cardiac hypertrophic growth and ensure oxygen and nutrition supply. Aldosterone and the mineralocorticoid receptor (MR) are key drivers of ...

ESAC Meeting 2018

The ESAC Symposium 2018 on Aldosterone and the Mineralocorticoid Receptor will take place at the Friedrich-Alexander University Erlangen-Nürnberg on 7th and 8th December 2018. It will be supported by the European ...
Cardiovascular Epigenetics Conference 2018

Cardiovascular Epigenetics Conference 2018

The 2nd Cardiovasvular Epigenetics Conference featuring well-recognized international speakers will take place in Freiburg, September 24th and 25th, 2018. Visit http://portal.uni-freiburg.de/pharmakologie for further information and registration. ...
Poster prize of the German Cardiac Society

Poster prize of the German Cardiac Society

Lisa Deng is awarded with a poster prize at this year’s annual meeting of the German Cardiac Society (DGK) for her presentation “Endothelial mineralocorticoid receptor deletion alters cardiac macrophage gene expression ...
Inhibition of the cardiac myocyte mineralocorticoid receptor ameliorates doxorubicin-induced cardiotoxicity

Inhibition of the cardiac myocyte mineralocorticoid receptor ameliorates doxorubicin-induced cardiotoxicity

Anthracyclines such as doxorubicin are widely used in cancer therapy but their use is limited by cardiotoxicity. Up to date there is no established strategy for the prevention of anthracyclin-induced ...
Awarded with an Otto-Hess-Scholarship

Awarded with an Otto-Hess-Scholarship

MD student Jessica Kowalski receives a prestigious Otto-Hess-Scholarship from the German Cardiac Society for her work on mineralocorticoid receptors in the cardiovascular system. With the scholarship, the society aims to ...
The cardiac endothelial cell transcriptome unravelled

The cardiac endothelial cell transcriptome unravelled

Endothelial cells provide a variety of highly specialized functions in different organs, e.g. as barrier, as sensor, or in nutrition supply, and cardiac endothelial cells play an important role in ...
Browse the Cardiac Epigenome

Browse the Cardiac Epigenome

The Cardiac Epigenome Browser is a resource for cell-type specific cardiac chromatin interaction and epigenome data. The project is located at the Institute of experimental and clinical Pharmacology and Toxicology, ...
UHZ Lecture 2017

UHZ Lecture 2017

Dr. Achim Lother received the Heart Center Freiburg University Young Investigator Award during this year’s UHZ Lecture. The Lecture was given by systems biology pioneer Professor Denis Noble, CBE FRS ...

Pharmacology of heart failure: From basic science to novel therapies

Chronic heart failure is one of the leading causes for hospitalization in the United States and Europe, and is accompanied by high mortality. Current pharmacological therapy of chronic heart failure ...

Abstract rated as Best of AHA Specialty Conferences 2016

The abstract by Lother et al., Cardiac Ly6Chigh Monocyte Accumulation and Remodeling Depend on the Mineralocorticoid Receptor in Endothelial Cells, which was presented at the American Heart Association Hypertension Council Meeting in 2016 has been ...

Vascular Mineralocorticoid Receptors: Linking Risk Factors, Hypertension, and Heart Disease

MR in endothelial cells and vascular smooth muscle cells are decisive mediators of cardiovascular remodeling. They contribute to blood pressure regulation and link cardiovascular risk factors and disease. Different cellular and molecular ...

Endothelial MR in hypertensive heart vs. kidney disease

Long-term arterial hypertension leads to heart and kidney injury. The goal of our study was to evaluate the effect of MR deletion in endothelial cells on organ damage in a ...

Recurrent pulseless electrical activity in a patient with coronary vasospasm and supravalvular aortic stenosis

Pulseless electrical activity cardiac arrest is associated with poor outcomes and the identification of potentially reversible reasons for cardiac arrest is fundamental. We describe the case of a 46-year-old male ...

Reviewed: Pharmacology of the Mineralocorticoid Receptor

Aldosterone regulates water and electrolyte homeostasis by activation of the mineralocorticoid receptor (MR), a ligand-activated transcription factor, in the kidney. Clinical trials have shown a striking benefit of MR antagonists ...